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Inhibition constant (Ki) values (μM) for the selected sp2-iminosugar chaperone candidates 1–4 against human β-glucocerebrosidase (GCase).1 Inhibition was competitive in all the cases.
| pH | 1 | 2 | 3 | 4 |
|---|---|---|---|---|
| 7 | 15.1 ± 0.97 | 0.26 ± 0.013 | 1.7 ± 0.066 | 0.013 ± 0.0011 |
| 5 | 54.4 ± 0.38 | 1.05 ± 0.068 | 6.3 ± 0.16 | 0.059 ±0.0035 |
1 Purified recombinant enzyme obtained from Sanofi Genzyme, Cambridge, MA, USA (Cerezyme®).
