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. 2018 Feb 24;23(2):501. doi: 10.3390/molecules23020501

Table 3.

Design matrix depicting actual and coded level combination and the corresponding response for a five-level, four-variable central composite rotatable designs.

Run Actual Levels Coded Levels Response, Yield (%)
X1 X2 X3 X4 X1 X2 X3 X4 Actual Predicted
1 3 1.10 38.0 10 −1 −1 −1 −1 27.4 23.4
2 7 1.10 38.0 10 1 −1 −1 −1 45.0 41.5
3 3 2.60 38.0 10 −1 1 −1 −1 42.3 40.1
4 7 2.60 38.0 10 1 1 −1 −1 58.9 58.2
5 3 1.10 46.0 10 −1 −1 1 −1 21.5 17.6
6 7 1.10 46.0 10 1 −1 1 −1 37.5 35.7
7 3 2.60 46.0 10 −1 1 1 −1 46.8 47.7
8 7 2.60 46.0 10 1 1 1 −1 61.8 65.8
9 3 1.10 38.0 20 −1 −1 −1 1 37.9 31.5
10 7 1.10 38.0 20 1 −1 −1 1 51.3 49.6
11 3 2.60 38.0 20 −1 1 −1 1 30.1 26.4
12 7 2.60 38.0 20 1 1 −1 1 38.0 44.5
13 3 1.10 46.0 20 −1 −1 1 1 43.0 42.1
14 7 1.10 46.0 20 1 −1 1 1 59.5 60.2
15 3 2.60 46.0 20 −1 1 1 1 48.7 50.5
16 7 2.60 46.0 20 1 1 1 1 66.0 68.6
17 1 1.83 42.0 15 −2 0 0 0 20.9 35.4
18 9 1.83 42.0 15 2 0 0 0 69.4 71.6
19 5 0.33 42.0 15 0 −2 0 0 10.1 19.2
20 5 3.33 42.0 15 0 2 0 0 50.3 44.2
21 5 1.83 34.0 15 0 0 −2 0 21.5 27.9
22 5 1.83 50.0 15 0 0 2 0 49.4 46.2
23 5 1.83 42.0 5 0 0 0 −2 42.6 48.1
24 5 1.83 42.0 25 0 0 0 2 58.6 59.0
25 5 1.83 42.0 15 0 0 0 0 61.1 53.5
26 5 1.83 42.0 15 0 0 0 0 57.7 53.5
27 5 1.83 42.0 15 0 0 0 0 59.3 53.5
28 5 1.83 42.0 15 0 0 0 0 50.3 53.5
29 5 1.83 42.0 15 0 0 0 0 60.6 53.5
30 5 1.83 42.0 15 0 0 0 0 48.8 53.5