Skip to main content
. 2018 Mar 28;23(4):776. doi: 10.3390/molecules23040776

Scheme 1.

Scheme 1

General synthesis scheme of xanthohumol derived compounds. Reagents and conditions: (a) DDQ, 1,4 dioxane, 95 °C (b) AlCl3, CH2Cl2, rt; (c) MOMCl, K2CO3, acetone, rt; (d) TFA, CH2Cl2, rt; (e) H2, 5% Pd/C, MeOH, rt; (f) aq 1% KOH, 0 °C; (g) AlCl3, MeCN, 50 °C; (h) aq 1% piperidine reflux (i) I2, pyridine, 90 °C; (j) anhydrous AlCl3, MeCN, rt.