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. 2018 Jun 6;53(2):633–643. doi: 10.3892/ijo.2018.4433

Figure 2.

Figure 2

Kaplan-Meier plot of the OS for the low- and high-risk group in the training dataset. Samples were divided into hypermethylation group and hypomethylation according to the median of the CAP-Gly domain containing linker protein family member 4 methylation values. Differentially expressed genes analysis was performed for the two groups. Three genes significantly associated with OS (P<0.005) were selected as the prognostic gene signatures. A risk assessment system was established based on the expression level of claudin-11, apolipoprotein D and chordin like 1. The patients in hyper-methylation group were divided into high- and low-risk groups according to median risk score. The prognosis of the patients in the low-risk group was significantly better than those in the high-risk group. OS, overall survival.