Table 2.

IC₅₀ values (μg/mL) of FKB derivatives after 72 h treatment.

Compounds Substituted Groups						IC50 Values (μg/mL)
Compounds	R1	R2	R3	R4	R5	MCF-7	MDA-MB-231
1	H	H	H	H	H	7.70 ± 0.30	5.90 ± 0.30
2	H	H	CH3O	H	H	8.90 ± 0.60	6.80 ± 0.45
3	H	H	SCH3	H	H	12.30 ± 1.40	18.10 ± 1.10
4	CH3O	CH3O	H	H	H	25.00 ± 1.80	21.10 ± 1.20
5	CH3O	H	CH3O	H	H	>30	>30
6	CH3O	H	CH3O	H	CH3O	>30	>30
7	H	CH3O	CH3O	H	H	9.70 ± 0.70	8.30 ± 0.56
8	CH3O	H	H	CH3O	H	>30	>30
9	H	CH3O	H	H	H	8.43 ± 0.40	7.22 ± 0.70
10	H	CH3O	H	CH3O	H	>30	>30
11	H	H	CH3	H	H	>30	>30
12	CH3O	H	H	H	H	>30	9.50 ± 0.60
13	F	H	H	H	H	7.12 ± 0.80	4.04 ± 0.30
14	H	H	F	H	H	>30	>30
15	H	Cl	H	H	H	5.50 ± 0.35	5.50 ± 0.40
16	Cl	H	H	H	H	6.50 ± 0.40	4.12 ± 0.20
17	H	H	Cl	H	H	>30	>30
18	H	H	Br	H	H	>30	>30
19	H	CH3O	OH	H	H	>30	27.00 ± 1.50
20	H	NO2	H	H	H	13.30 ± 3.10	17.10 ± 2.15
21	H	H	N(CH3)2	H	H	>30	20.5 ± 1.60
22	OH	H	H	Br	H	6.50 ± 0.35	14.16 ± 1.10
23	Br	OH	OCH3	H	H	>30	>30