Table 3.
Review of published CYP inhibition research for key phytochemicals.
| Phytochemicals | Reported CYP Inhibition | IC50 Value (μM) | Reference |
|---|---|---|---|
| Podophyllotoxin | CYP3A4 | Potent inhibitor (IC50 not stated) | [40] |
| Dehydropodophyllotoxin | None | - | |
| Deoxydehydropodophyllotoxin | None | - | |
| 4′-Demethyldesoxypodophyllotoxin | None | - | |
| 4′-Demethylpodophyllotoxin | None | - | |
| 5′-Methoxydehydropodophyllotoxin | None | - | |
| Dehydro-β-peltatin methyl ether | None | - | |
| (-)-yatein | CYP3A4 CYP2D6 |
1.095.7 | [39] [39] |
| Oleanolic acid | CYP1A2 CYP2C8/C9/C19 CYP3A4 CYP2D6 |
143.5 >500 78.9 >500 |
[38] [38] [38] [38] |
| Ursolic acid | CYP1A2 CYP2C8/C9/C19 CYP3A4 CYP2D6 |
352.4 >500 >500 438.9 |
[38] [38] [38] [38] |
| Rosmarinic acid | CYP2C9 CYP2D6 CYP3A4 CYP3A4 |
318.9 >500 241.2 No impact |
[49] [49] [49] [50] |
| ß-Sitosterol | CYP2D6 CYP3A4 CYP3A4/3A5 CYP2C19 |
>100 >100 No impact No impact |
[51] [51] [52] [52] |