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. 2018 Jan 4;23(1):102. doi: 10.3390/molecules23010102

Scheme 2.

Scheme 2

Synthesis of compounds 2225 (Procedure B). Reagents and conditions: (i) (COCl)2, DMF, carboxylic acids 1013, CH2Cl2, 0 °C→r.t., 1 h; (ii) Et3N, CH2Cl2, 0 °C→r.t., 1 h, 81–91%.