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Difference in binding affinity of cyanidin to ERα and ERβ. Hydrogen bonds of each compound and ERs are indicated as blue dotted lines. Red, blue, and black circles indicate position 1, position 2, and aryl ring, respectively. Red arrows indicate hydroxyl groups. (a) Interaction of cyanidin with ERα; (b) cyanidin with ERβ; (c) genistein with ERα; and (d) genistein with ERβ.
