Figure 2.

Inhibitory activity of ruthenium complexes (TQ-1-TQ3) on (A) collagen and (B) thrombin–induced platelet aggregation in washed human platelets. Washed human platelets (3.6 × 10⁸ cells/mL) were pre-incubated with the solvent control (0.1% DMSO) or TQ-1, TQ-2 (50–250 μM) and TQ-3 (1–5 μM) and then treated with 1 μg/mL collagen and 0.01 U/mL thrombin to stimulate platelet aggregation. Data are presented as means ± standard errors of the means (n = 4). * p < 0.05, *** p < 0.001 compared with the DMSO group.