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. 2018 May 25;53(2):672–684. doi: 10.3892/ijo.2018.4421

Figure 5.

Figure 5

Knockdown of WAVE3 suppresses the migratory and invasive potentials of the cells by influencing the EMT process in the PANC-1 and CFPAC-1 cell lines. (A and B) Wound healing (magnification, ×50) and Transwell migration (magnification, ×200) assays indicated that WAVE3 knockdown suppressed the migratory capabilities of pancreatic cancer cells (*P<0.05 vs. the NC siRNA-transfected cells). (C) Transwell invasion assays (magnification, ×200) showed that the invasion potentials were decreased in the cells in which WAVE3 was knocked down compared with the controls (*P<0.05 vs. the NC siRNA-transfected cells). (D) WAVE3 suppression affected EMT, resulting in the acquirement of an epithelial-like phenotype in the pancreatic cancer cell lines. *P<0.05 vs. the NC siRNA-transfected cells. WAVE3, Wiskott-Aldrich syndrome protein family verprolin-homologous protein 3; EMT, epithelial-mesenchymal transition.