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. 2018 May 25;53(2):672–684. doi: 10.3892/ijo.2018.4421

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Knockdown of WAVE3 negatively affects the survival of pancreatic cancer cells lines. (A and B) Cell growth potential was inhibited in the pancreatic cancer cell lines following transfection with WAVE3 siRNA, as demonstrated by the plate clone formation and CCK-8 assays (^*P<0.05 vs. the NC siRNA-trans-fected cells). (C) Flow cytometry demonstrated that the percentages of apoptosis were increased in both cell lines following the knockdown of WAVE3 (^*P<0.05) (D) Western blot analyses revealed that the expression of cell survival-related proteins (p53 and Bcl-2) was altered following the knockdown of WAVE3 in the PANC-1 and CFPAC-1 cell lines. ^*P<0.05 vs. the NC siRNA-transfected cells. WAVE3, Wiskott-Aldrich syndrome protein family verprolin-homologous protein.