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Inhibitory effect of varespladib on hemorrhagic toxicity. (A) Severe hemorrhage and ulceration were caused by subcutaneous injection of A. halys and D. acutus venom, in contrast to varespladib-treated mice that had intact blood vessels and showed mild symptoms; and (B) varespladib significantly reduced the integrated density of hemorrhagic plaques (**** p < 0.0001).
