Table 1.
Cell growth inhibitory activities of the extracts, fractions and isolated compounds against cancer and noncancerous (PNT2) cells *.
| IC50 Values | ||||
|---|---|---|---|---|
| Extracts/Fractions (µg/mL) | A549 | MCF-7 | PC-3 | PNT2 |
| Hexane extract | >250 | 71.7 ± 1.5 | 31.5 ± 0.9 | nd |
| DCM extract | >250 | 59.7 ± 3.0 | >250 | nd |
| MeOH extract | >250 | >250 | >250 | nd |
| D1 | 39.5 ± 2.9 | 106.0 ± 4.2 | 209.3 ± 7.6 | nd |
| D2 | 54.9 ± 1.7 | 20.2 ± 1.2 | 39.9 ± 2.9 | nd |
| D3 | 126.8 ± 1.2 | 52.5 ± 0.5 | 90.3 ± 0.6 | nd |
| D4 | 44.4 ± 3.1 | 52.2 ± 0.3 | 104.3 ± 4.9 | nd |
| D5 | >250 | >250 | >250 | nd |
| D6 | >250 | 66.2 ± 1.5 | >250 | nd |
| H1 | 147.5 ± 1.5 | 84.5 ± 5.2 | 13.2 ± 0.0 | nd |
| H2 | 102.2 ± 0.9 | 103.7 ± 4.9 | 109.3 ± 3.7 | nd |
| H3 | >250 | 173.1 ± 4.9 | >250 | nd |
| H4 | 106.6 ± 6.6 | 60.6 ± 1.2 | 211.8 ± 10.1 | nd |
| H5 | 49.9 ± 5.5 | 42.7 ± 12.5 | >250 | nd |
| H6 | >250 | 150.4 ± 5.9 | >250 | nd |
| Compounds (µM) | ||||
| 1 | 63.8 ± 13.8 | 136.2 ± 22.7 | >200 | >200 |
| 2 | 138.6 ± 22.1 | 171.3 ± 51.4 | >200 | >200 |
| 3/4 | 128.6 ± 31.0 | >200 | 111.2 ± 2.9 | >200 |
| 5 | 106.6 ± 27.2 | >200 | >200 | >200 |
| 6/7 | >200 | >200 | 160.9 ± 36.2 | >200 |
| 8 | >200 | >200 | >200 | >200 |
| 9 | 136.8 ± 18.9 | >200 | 172.3 ± 39.7 | 167.5 ± 25.3 |
| 10 | >200 | >200 | 135.6 ± 21.1 | >200 |
| Doxorubicin | 1.3 ± 0.3 | 0.7 ± 0.1 | 16.4 ± 2.9 | 1.5 ± 0.3 |
* Data are represented as mean ± SEM (n = 3); IC50 = sample concentration that caused 50% cell growth inhibition; nd = not determined.