Table 2.
In vitro targeted delivery of siRNAs to HCC.
| Delivery Material | HCC Targeting Antigen | HCC Model | siRNA mRNA Target | Reference |
|---|---|---|---|---|
| Galactose modified trimethylchitosan-cystein (GTC) | ASGP-R | BEL-7402 | Survivin and VEGF | [108] |
| PEI grafted with stearic acid (PEI-SA) | FR | HuH-7 | VEGF | [111] |
| GalNac- PEG-b-PCL and PCL-b-PPEEA | ASGP-R | Primary hepatocytes | apolipoprotein B | [112] |
| Inulin and diethylentriamine (Inu-DETA) on α,β-poly-(N-2-hydroxyethyl)-d,l-aspartamide (PHEA) and DETA and PEG) and GAL molecules (PHEA-DETA-PEG-GAL) |
Trafficking specificity | JHH6 | E2F1 | [52] |
| ASGP-R | JHH6 | E2F1 | [113] |