Table 2.
The information of major potential targets of JGB in liver diseases.
| Target Gene | Target Protein | Biological Effects Associated with Liver Diseases |
|---|---|---|
| CYP2E1 | Cytochrome P450 2E1 | Oxidative stress and fatty acid oxidation |
| PPARD | Peroxisome proliferator-activated receptor delta | Integrator of transcription repression and nuclear receptor signaling, lipid accumulation |
| IGF1 | Insulin-like growth factor 1 | Activators of the AKT signaling pathway, cell death |
| TPO | Thyroid peroxidase | Primary regulator of platelet production |
| ANXA1 | Annexin 1 | Anti-inflammation |
| ADIPOQ | Adiponectin | Modulates glucose regulation and fatty acid oxidation |
| PROC | Protein C | Anticoagulant protein, marker in determining the severity of the liver disease |
| CCL5 | Chemokine CCL5 | Mediate the interaction between immune cells and hepatic stellate cells |
| FOXP3 | Forkhead box P3 | Regulatory T cells, immune cells regulation |
| IL10 | Interleukin-10 | Modulate Kupffer cells, liver inflammation and fibrosis |
| IL6 | Interleukin-6 | Pro-inflammation and anti-inflammation |
| SREBF1 | Sterol regulatory element-binding transcription factor 1 | Glucose metabolism, fatty acid and lipid production |
| TNF | Tumor necrosis factor | Activates several intracellular pathways to regulate inflammation, cell death, and proliferation |
| CD34 | CD34 protein | Facilitate cell migration, dedifferentiation |
| TGF-β | Transforming growth factor-β | Inflammation, wound healing, hepatocyte damage, hepatocyte proliferation, fibrogenesis |