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Effects of compounds 1 and 2 on melanogenesis in melan-a cells. The cells were cultured with 0–80 µM of eight compound for four days. Inhibition of melanin synthesis was measured with triplicate experiments. Data are expressed a means ± SD of triplicate determinations. * p < 0.05, ** p < 0.01, *** p < 0.001 versus the control group.
