Table 2.

Summary of the experimental conditions. We chose to use, for each preparation, the maximum activity and the maximum volume allowed by the manufacturer.

Compound	Synthesis	Quality Control System	Quality Control Time
Ceretec (GE Healthcare) [99mTc]Tc-HMPAO N = 24	Volume: 5 mL Activity: 1.10 GBq 1 Incubation Time: 30 s Package leaflet: 03/2016	TLC-SA Methylethylketone (MEK)	0 min, 15 min, 30 min
		TLC-SA physiological solution
MAASOL (GE Healthcare) [99mTc] Tc-albumin colloid N = 24	Volume: 8 mL Activity: 2.96 GBq Incubation Time: 5 min Package leaflet: 03/2015	ITLC-SG Methanol:water (85:15, v:v)	0 h, 3 h, 6 h
Nanocoll (GE Healthcare) [99mTc]Tc-nanocolloid N = 80	Volume: 5 mL Activity: 5.55 GBq Incubation Time: 30 min Package leaflet: 11/2015	TLC-SA Methanol:water (85:15, v:v)	0 h, 3 h, 6 h
Renocis (IBA molecular) [99mTc]Tc-DMSA N = 8	Volume: 6 mL Activity: 3.70 GBq Incubation Time: 10 min Package leaflet: 05/2011	Whatman n.1 MEK	0 h, 4 h, 8 h
Technemibi (Mallinckrodt) [99mTc]Tc-MIBI N = 24	Volume: 3 mL Activity: 11.10 GBq Incubation Time: 10 min, 100 °C Package leaflet: 10/2014	Baker flex aluminum oxide Ethanol >95%	0 h, 5 h, 10 h
Technescan HDP (Mallinckrodt) [99mTc]Tc-HDP N = 60	Volume: 10 mL Activity: 11.10 GBq Incubation Time: 30 s Package leaflet: 08/2017	TLC-SG 13.6% sodium acetate	0 h, 4 h, 8 h
		TLC-SG MEK
Technescan MAG3 (Mallinckrodt) [99mTc]Tc-MAG3 N = 24	Volume: 10 mL Activity: 2.96 GBq 2 Time: 10 min, 120 °C Package leaflet: 02/2017	RP-18 54/45/1 (saline/methanol/glacial acetic acid)	0 h, 4 h, 8 h

¹ Fresh sodium pertechnetate (not older than 2 h) obtained by generator eluted not more than 24 h before. ² Fresh sodium pertechnetate obtained by generator (generator not older than 1 week from manufacturing) eluted not more than 24 h before. Where not specified, the incubation temperature during the synthesis, inside the isolator, was detected by our measurement. Finally, the production process of ^99mTc-radiopharmaceuticals is constantly subjected to the Fill average test.