Table 5.
Status of some of the major global clinical trials of curcumin in aging-associated diseases.
| ClinicalTrials.gov Identifier | Ages (Years) | Disease | Doses of Curcumin | Phase | Reference |
|---|---|---|---|---|---|
| NCT02998918 | 18 to 60 (Adult) | Inflammation Atherosclerosis Cardiovascular Disease |
500 mg of curcumin phytosome twice daily for 1 week | 2 | [85] |
| NCT00973869 | 18 and older (Adult, Senior) | Colorectal cancer | Oral curcumin once daily for 14–28 days | 1 | [86] |
| NCT02099890 | 18 and older (Adult, Senior) | Neuropathic pain; Depression; Cognitive impairment; Somatic neuropathy; Autonomic dysfunction |
InflanNox capsule (400 mg curcumin) taken 3 times daily along with other anti-inflammatory supplements | 3 | [87] |
| NCT02369549 | 18 and older (Adult, Senior) | Chronic kidney disease | Three 30 mg capsules of micro-particle curcumin daily in the morning | 3 | [88] |
| NCT02529969 | 40 to 65 (Adult) | Non-insulin dependent diabetes | 500 mg curcumin capsule | 2 | [89] |
| NCT02984813 | 18 and older (Adult, Senior) | Open-angle glaucoma diabetic retinopathy | Two pills daily (one contains curcumin and other contains active compounds) for 3 months | 1 | [90] |
| NCT00164749 | 50 and older (Adult, Senior) | Alzheimer’s disease | Two different dosages (1 g/day and 4 g/day) along with ginkgo extract | 2 | [91] |
| NCT00752154 | 18 and older (Adult, Senior) | Rheumatoid arthritis | Curcumin (Longvida™) 4 capsules approximately 2 g/day for 2 weeks, then the dose will be increased to 4 capsules twice a day (4 g/day) | Early phase 1 | [92] |