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Roles of galectin-3 at extracellular and intracellular levels. At extracellular level Gal3 participates in cell adhesion. In intracellular level Gal3 activates different signalization pathways as MAPK, PI3K/Akt and Wnt that induces cell proliferations, apoptosis or bind to integrin receptors that activate VEGF to induce angiogenesis [198].
