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. 2018 Apr 4;23(4):826. doi: 10.3390/molecules23040826

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Schematic illustration of composition/structure of the HA-Hybrid NPs, and its binding to CD44 on breast cancer stem cells (bCSCs); (b) The cell viability of MCF7 mammosphere cells after treated with different drug formulations at varying concentration for 48 h; (c) the relative volume of the mammosphere at the end of treatment (volume normalized to that at 0 day); (d) the tumor weight at the experimental end point (20th day); reproduced with the permission from [75], Copyright (2017) The Royal Society of Chemistry.