Table 2.
Cytotoxicities of compounds 1–6 against five human cancer cell lines in vitro (IC50, μM) a.
| Compounds | Cell Lines | ||||
|---|---|---|---|---|---|
| SMMC-7721 | Bel-7402 | A549 | H460 | K562 | |
| b 5-Fu | 2.4 ± 1.9 | 4.3 ± 2.1 | 4.0 ± 1.6 | 1.7 ± 2.8 | 1.0 ± 0.9 |
| 1 | 10.4 ± 3.9 | 13.3 ± 4.6 | >100 | 33.7 ± 2.2 | 25.5 ± 3.5 |
| 2 | 11.2 ± 4.4 | 6.9 ± 1.7 | 14.4 ± 2.8 | 26.2 ± 2.7 | 29.3 ± 5.3 |
| 3 | 8.6 ± 3.4 | 11.4 ± 4.1 | >100 | 31.4 ± 1.7 | 24.2 ± 2.9 |
| 4 | 7.2 ± 4.6 | 4.4 ± 1.1 | 12.3 ± 2.5 | 21.8 ± 2.1 | >100 |
| 5 | 7.4 ± 5.8 | 31.9 ± 2.1 | >100 | 34.4 ± 3.2 | 15.8 ± 5.4 |
| 6 | 8.8 ± 5.3 | 30.3 ± 2.4 | >100 | 30.3 ± 3.7 | 12.3 ± 5.5 |
a IC50 values are means from three independent experiments (average ± SD) in which each compound concentration was tested in three replicate wells; b 5-fluorouracil (5-Fu) as positive control.