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. 2017 Dec 31;23(1):85. doi: 10.3390/molecules23010085

Table 1.

The structures and the hedgehog pathway inhibition of target compounds.

graphic file with name molecules-23-00085-i001.jpg

Compd. R Gli-luc Reporter IC50 a (μmol/L) Compd. R Gli-luc Reporter IC50 a (μmol/L)
5a graphic file with name molecules-23-00085-i002.jpg 28.52 ± 0.02 5l graphic file with name molecules-23-00085-i003.jpg 1.83 ± 0.03
5b graphic file with name molecules-23-00085-i004.jpg 12.47 ± 0.11 5m graphic file with name molecules-23-00085-i005.jpg 10.49 ± 0.05
5c graphic file with name molecules-23-00085-i006.jpg 14.63 ± 0.01 5n graphic file with name molecules-23-00085-i007.jpg 5.32 ± 0.13
5d graphic file with name molecules-23-00085-i008.jpg 15.51 ± 0.03 5o graphic file with name molecules-23-00085-i009.jpg 4.28 ± 0.01
5e graphic file with name molecules-23-00085-i010.jpg 17.59 ± 0.15 5p graphic file with name molecules-23-00085-i011.jpg 3.43 ± 0.08
5f graphic file with name molecules-23-00085-i012.jpg 53.34 ± 0.07 5q graphic file with name molecules-23-00085-i013.jpg 1.26 ± 0.03
5g graphic file with name molecules-23-00085-i014.jpg 60.56 ± 0.04 8a graphic file with name molecules-23-00085-i015.jpg 6.88 ± 0.13
5h graphic file with name molecules-23-00085-i016.jpg 7.85 ± 0.01 8b graphic file with name molecules-23-00085-i017.jpg 12.7 ± 0.16
5i graphic file with name molecules-23-00085-i018.jpg 16.32 ± 0.05 8c graphic file with name molecules-23-00085-i019.jpg 8.62 ± 0.09
5j graphic file with name molecules-23-00085-i020.jpg 4.74 ± 0.02 MRT10 b 2.15
5k graphic file with name molecules-23-00085-i021.jpg 16.61 ± 0.12 Vismodegib b 0.025

a The values are an average of triplicate separate determinations. b Used as a positive control.