Table 5.

SSD/PF-related compound Ka and thermodynamic parameters.

Drug	°C	Ka	n	ΔG	ΔS	ΔH	Reaction System	Reference
PF	25	3.56 × 104	0.62	−21.0	103.5	4.1	10–70 μM PF, 10 μM BSA, pH7.4 Tris-HCL	[34]
	37	3.78 × 104	0.61	−22.0
PF	15	1.91 × 103	0.91	−18.1	28.2	−10.0	2.5–12.5 μM PF, 10 μM BHSA, pH7.4 Tris-HCL	[24]
	37	1.42 × 103	0.89	−18.7
Paeonol	10	1.58 × 104	1.01	−22.7	88.7	2.4	10–70 μM paenol, 1 μM BHSA, pH7.4 Tris-HCL	[35]
	40	9.68 × 102	0.84	−17.9	64.9
Paeonol	4	1.33 × 104	-	−22.0	−6.3	−23.8	pH7.4 PBS	[28]
	37	3.55 × 103	-	−21.8
SSC	26	3.72 × 103	0.79	−20.34	−90.3	−47.3	1–15 μM PF, 2 μM BHSA, pH7.4 PBS	[26]

K_a, mol·L⁻¹; ΔG,kJ·mol⁻¹; ΔS, J·mol⁻¹·K⁻¹; ΔH, kJ·mol⁻¹; PF, paeoniflorin; SSC, saikosaponin C.