Table 1.

PK parameters of leuprolide after IV and SC administration of leuprolide solution (mean ± standard error (SE), n = 5).

Parameters	IV (Group 1)	SC (Group 3)
k (h−1)	1.42 ± 0.24	1.06 ± 0.55
ka(h−1)	-	16.67 ± 2.55
CL (mL/h)	248.61 ± 35.07	514.46 ± 40.10
Vd(mL)	192.95 ± 54.24	487.40 ± 29.02
Cmax(ng/mL)	97.10 ± 13.04 a	41.53 ± 4.61
t1/2 (h)	0.52 ± 0.10	0.66 ± 0.03
AUC0-t (h·ng/mL)	103.44 ± 16.93	51.20 ± 9.56
AUC0–∞ (h·ng/mL)	105.50 ± 17.27	53.33 ± 9.96
F (%)	100	50.6

^a The concentration is the C₀ (ng/mL) after IV administration.