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Inhibition of human recombinant AKR1B1 by compounds 1–5.
| Comp. | IC50 (μM) a |
|---|---|
| 1 | 8.9 (6.5–12.1) |
| 2 | 17.4 (14.3–21.2) |
| 3 | 21.0 (12.8–34.3) |
| 4 | 31.7 (22.3–44.9) |
| 5 | 23.3 (19.0–25.5) |
| Sorbinil | 1.2 (0.9–1.5) |
a 95% confidence intervals are reported in brackets.
