Table 3.

Toxicity profiles predicted for compounds 1–3, pioglitazone, sorbinil and glibenclamide.

Compd	LD50 (mg/kg)				Probability of Inhibition (IC50 or Ki < 10 μM)
	Mouse		Rat		CYP450 Isoform			hERG
	i.p.	p.o.	i.p.	p.o.	3A4	2D6	1A2
1	320	1400	560	3800	0.08	0.05	0.17	0.10
2	530	2000	460	2700	0.07	0.05	0.15	0.04
3	580	1990	1200	4000	0.07	0.02	0.04	0.13
Pioglitazone	440	1900	400	1100	0.22	0.03	0.08	0.21
Sorbinil	420	680	190	1600	0.02	0.02	0.01	0.10
Glibenclamide	980	1900	500	2400	0.20	0.08	0.01	0.60