Table 2.
Distribution of rs1412125 and rs1360485 and lung cancer risk.
| Genotype | Cases (%) | Controls (%) | OR(95% CI) * | p-Value | HWE |
|---|---|---|---|---|---|
| rs1412125 | 0.529 | ||||
| TT | 511 (60.1%) | 396 (54.0%) | 1 | ||
| CT | 296 (34.8%) | 290 (39.6%) | 0.744(0.599, 0.924) | 0.008 | |
| CC | 43 (5.1%) | 47 (6.4%) | 0.684 (0.434, 1.077) | 0.101 | |
| Dominant model | |||||
| TT | 511 (60.1%) | 396 (54.0%) | 1 | 0.004 | |
| CT + CC | 339 (39.9%) | 337 (46.0%) | 0.736 (0.597, 0.906) | ||
| Recessive model | |||||
| TT + CT | 807 (94.9%) | 686 (93.6%) | 1 | 0.247 | |
| CC | 43 (5.1%) | 47 (6.4%) | 0.769 (0.493, 1.200) | ||
| Allele model | |||||
| T allele | 1318 (77.5%) | 1082 (73.8%) | 1 | 0.102 | |
| C allele | 382 (22.5%) | 384 (26.2%) | 0.769 (0.561, 1.053) | ||
| rs1360485 | 0.945 | ||||
| AA | 579 (68.1%) | 464 (63.3%) | 1 | ||
| AG | 245 (28.8%) | 238 (32.5%) | 0.836 (0.668, 1.046) | 0.117 | |
| GG | 26 (3.1%) | 31 (4.2%) | 0.667 (0.381, 1.168) | 0.157 | |
| Dominant model | |||||
| AA | 579 (68.1%) | 464 (63.3%) | 1 | 0.066 | |
| AG + GG | 271 (31.9%) | 269 (36.7%) | 0.816 (0.658, 1.013) | ||
| Recessive model | |||||
| AA + AG | 824 (96.9%) | 702 (95.8%) | 1 | 0.219 | |
| GG | 26 (3.1%) | 31 (4.2%) | 0.706 (0.405, 1.231) | ||
| Allele model | |||||
| A allele | 1403 (82.5%) | 1166 (79.5%) | 1 | 0.047 | |
| G allele | 297 (17.5%) | 300 (20.5%) | 0.829 (0.689, 0.998) |
HWE, Hardy-Weinberg equilibrium; OR, Odd ratio; 95% CI, 95% Confidence Interval; *OR was adjusted by age, gender and smoking.