Table 3.
Stratification analysis of rs1412125 polymorphisms and risk of lung cancer.
| Histology | Genotype | Cases (%) | Controls (%) | OR(95% CI) * | p-Value |
|---|---|---|---|---|---|
| LAD | TT | 302 (59.6%) | 396 (54.0%) | 1 | |
| CT | 180 (35.5%) | 290 (39.6%) | 0.764 (0.598,0.975) | 0.031 | |
| CC | 25(4.9%) | 47 (6.4%) | 0.680 (0.405, 1.143) | 0.146 | |
| Dominant model | |||||
| TT | 302 (59.6%) | 396 (54.0%) | 1 | 0.018 | |
| CT + CC | 205 (40.4%) | 337 (46.0%) | 0.752 (0.595, 0.951) | ||
| Recessive model | |||||
| TT + CT | 482 (95.1%) | 686 (93.6%) | 1 | 0.287 | |
| CC | 25 (4.9%) | 47 (6.4%) | 0.759 (0.456, 1.262) | ||
| LSCC | TT | 125 (59.0%) | 396 (54.0%) | 1 | |
| CT | 75 (35.4%) | 290 (39.6%) | 0.807 (0.560, 1.162) | 0.249 | |
| CC | 12 (5.6%) | 47 (6.4%) | 0.706 (0.333, 1.498) | 0.364 | |
| Dominant model | |||||
| TT | 125 (59.0%) | 396 (54.0%) | 1 | 0.191 | |
| CT + CC | 87 (41.0%) | 337 (46.0%) | 0.792 (0.558, 1.123) | ||
| Recessive model | |||||
| TT + CT | 200 (94.3%) | 686 (93.6%) | 1 | 0.487 | |
| CC | 12 (5.7%) | 47 (6.4%) | 0.770 (0.368, 1.610) | ||
| SCLC | TT | 69 (65.1%) | 396 (54.0%) | 1 | |
| CT | 31 (29.2%) | 290 (39.6%) | 0.576 (0.364, 0.911) | 0.018 | |
| CC | 6 (5.7%) | 47 (6.4%) | 0.719 (0.291, 1.777) | 0.475 | |
| Dominant model | |||||
| TT | 69 (65.1%) | 396 (54.0%) | 1 | 0.019 | |
| CT + CC | 37 (34.9%) | 337 (46.0%) | 0.595 (0.386, 0.918) | ||
| Recessive model | |||||
| TT + CT | 100 (94.3%) | 686 (93.6%) | 1 | 0.787 | |
| CC | 6 (5.7%) | 47 (6.4%) | 0.885 (0.363, 2.154) |
LAD, lung adenocarcinoma; LSCC, lung squamous cell carcinoma; SCLC, small cell lung cancer; OR, Odd ratio; 95% CI, 95% Confident Interval; * OR was adjusted by age, gender and smoking.