Table 5.
Crossover analysis of interaction between SNPs and tobacco exposure in northeast Chinese population.
| Genotype | Smoking | Cases (%) | Controls (%) | OR(95% CI) * | p-Value |
|---|---|---|---|---|---|
| rs1412125 | |||||
| CT + CC | — | 226 (28.0%) | 246 (40.7%) | 1 | |
| TT | — | 339 (42.1%) | 276 (45.7%) | 1.339 (1.053, 1.703) | 0.017 |
| CT + CC | + | 100 (12.4%) | 41 (6.8%) | 2.467 (1.571, 3.875) | <0.001 |
| TT | + | 141 (17.5%) | 41 (6.8%) | 3.465 (2.222, 5.401) | <0.001 |
| rs1360485 | |||||
| AG + GG | — | 188 (23.3%) | 192 (31.8%) | 1 | |
| AA | — | 377 (46.8%) | 330 (54.6%) | 1.169 (0.911, 1.500) | 0.220 |
| AG + GG | + | 70 (8.7%) | 31 (5.2%) | 2.150 (1.297, 3.566) | 0.003 |
| AA | + | 171 (21.2%) | 51 (8.4%) | 3.173 (2.074, 4.855) | <0.001 |
OR, Odd ratio; 95% CI, 95% Confident Interval; * OR was adjusted by age and gender.