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. 2018 Mar 2;23(3):567. doi: 10.3390/molecules23030567

Table 2.

Structure-Activity Relationship (SAR) of DC-S303 and its derivatives.

graphic file with name molecules-23-00567-i001.jpg

No. R1 R2 R3 Inhibition Ratio at 100 μM/% IC50 (μM)
DC-S303 graphic file with name molecules-23-00567-i002.jpg Inline graphic
(A)		 graphic file with name molecules-23-00567-i014.jpg 99 1.1
DC-S304 graphic file with name molecules-23-00567-i003.jpg 44
DC-S305 graphic file with name molecules-23-00567-i004.jpg −5
DC-S306 graphic file with name molecules-23-00567-i005.jpg 94 20
DC-S307 graphic file with name molecules-23-00567-i006.jpg 8
DC-S308 graphic file with name molecules-23-00567-i007.jpg 7
DC-S309 graphic file with name molecules-23-00567-i008.jpg −5
DC-S310 graphic file with name molecules-23-00567-i009.jpg −6
DC-S311 graphic file with name molecules-23-00567-i010.jpg 97 13
DC-S312 graphic file with name molecules-23-00567-i011.jpg −3
DC-S313 graphic file with name molecules-23-00567-i012.jpg −6
DC-S314 graphic file with name molecules-23-00567-i015.jpg Inline graphic
(B)		 graphic file with name molecules-23-00567-i017.jpg 77 46
DC-S315 graphic file with name molecules-23-00567-i018.jpg 46
DC-S316 graphic file with name molecules-23-00567-i019.jpg 37
DC-S317 graphic file with name molecules-23-00567-i020.jpg 29
DC-S318 graphic file with name molecules-23-00567-i021.jpg 17
DC-S319 graphic file with name molecules-23-00567-i022.jpg 14
DC-S320 graphic file with name molecules-23-00567-i023.jpg 11
DC-S321 graphic file with name molecules-23-00567-i024.jpg 9
DC-S334 graphic file with name molecules-23-00567-i025.jpg Inline graphic
(C)		 graphic file with name molecules-23-00567-i027.jpg 96 9.9
DC-S335 graphic file with name molecules-23-00567-i028.jpg 12 IC50 (μM)
DC-S336 graphic file with name molecules-23-00567-i029.jpg 49 1.1
DC-S337 graphic file with name molecules-23-00567-i030.jpg 1
DC-S338 graphic file with name molecules-23-00567-i031.jpg 1
DC-S339 graphic file with name molecules-23-00567-i032.jpg −6 20
DC-S340 graphic file with name molecules-23-00567-i033.jpg −6
DC-S341 graphic file with name molecules-23-00567-i034.jpg −10
DC-S342 graphic file with name molecules-23-00567-i035.jpg −13
DC-S343 graphic file with name molecules-23-00567-i036.jpg Inline graphic
(D)		 graphic file with name molecules-23-00567-i038.jpg 1
DC-S344 graphic file with name molecules-23-00567-i039.jpg 32 13
DC-S345 graphic file with name molecules-23-00567-i040.jpg 29
DC-S346 graphic file with name molecules-23-00567-i041.jpg 21
DC-S347 graphic file with name molecules-23-00567-i042.jpg 10
DC-S348 graphic file with name molecules-23-00567-i043.jpg −11
DC-S349 graphic file with name molecules-23-00567-i044.jpg −1
DC-S350 graphic file with name molecules-23-00567-i045.jpg 6
DC-S351 graphic file with name molecules-23-00567-i046.jpg 96 3.4
DC-S352 graphic file with name molecules-23-00567-i047.jpg 39
DC-S353 graphic file with name molecules-23-00567-i048.jpg 35
DC-S354 graphic file with name molecules-23-00567-i049.jpg 35
DC-S355 graphic file with name molecules-23-00567-i050.jpg 20
DC-S356 graphic file with name molecules-23-00567-i051.jpg 17
DC-S357 graphic file with name molecules-23-00567-i052.jpg 13
DC-S358 graphic file with name molecules-23-00567-i053.jpg 6
DC-S359 graphic file with name molecules-23-00567-i054.jpg 5
DC-S360 graphic file with name molecules-23-00567-i055.jpg 4
DC-S361 graphic file with name molecules-23-00567-i056.jpg −1
DC-S362 graphic file with name molecules-23-00567-i057.jpg −4
DC-S363 graphic file with name molecules-23-00567-i058.jpg −15
DC-S364 graphic file with name molecules-23-00567-i059.jpg 54 3.7
DC-S365 graphic file with name molecules-23-00567-i060.jpg Inline graphic
(E)		 graphic file with name molecules-23-00567-i062.jpg 10
DC-S366 graphic file with name molecules-23-00567-i063.jpg 9
DC-S367 graphic file with name molecules-23-00567-i064.jpg −1