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Synthesis procedure for the preparation of 2-substituted indoles (9). Reagents and conditions: (a) chloroacetonitrile, AlCl3, BCl3, CH2Cl2, 0 °C to reflux, 7–23 h; and (b) Grignard reagent R2-MgHal, THF or toluene, −10 °C to rt, 60 min; for substituents R1 and R2 refer to Table 1.
