Table 1.
Incidence, mean day of onset and mean maximal score of myelin basic protein 72–85 epitope (MBP72–85)-induced experimental autoimmune encephalomyelitis (EAE) in female Lewis rats, nonvaccinated (control) or vaccinated two days before (prophylactic) and two days after (early therapeutic) induction of EAE, with cyclo(87–99)[Arg91, Ala96]MBP87–99, as shown in three independent experiments (experiments 1–3). Data are also shown (experiment 4) from MBP72–85-EAE in groups of rats that were treated prophylactically 23 days before immunization. Mean day of onset and mean maximal score are presented as mean ± SEM.
| Rats | Incidence | Mean Day of Onset | Mean Maximal Score |
|---|---|---|---|
| Expt1 | |||
| Control | 3/3 (100%) | 11.00 ± 1.08 | 2.60 ± 0.27 |
| Prophylactic vac d − 2 | 1/3 (33.3%) | 15.00 | 1.00 ± 0.27 |
| Therapeutic vac d + 2 | 1/3 (33.3%) | 12.00 | 1.00 ± 0.27 |
| Expt2 | |||
| Control | 6/6 (100%) | 8.16 ± 0.15 | 3.00 ± 0.35 |
| Prophylactic vac d − 2 | 4/6 (66.6%) | 9.25 ± 0.45 | 0.41 ± 0.14 |
| Therapeutic vac d + 2 | 5/6 (83.4%) | 10.40 ± 1.25 | 1.25 ± 0.32 |
| Expt3 | |||
| Control | 6/6 (100%) | 11.30 ± 0.45 | 2.60 ± 0.34 |
| Prophylactic vac d − 2 | 5/6 (83.4%) | 12.00 ± 0.32 | 1.58 ± 0.41 |
| Expt4 | |||
| Control | 4/4 (100%) | 9.30 ± 0.27 | 3.33 ± 0.13 |
| Prophylactic vac d − 23 | 4/4 (100%) | 12.75 ± 0.41 | 1.87 ± 0.44 |