Table 2.

Glucuronide conjugates formed by incubation with HLM.

Metabolite a	tR (min) b	Substrate	MRM Transitions	EPI Fragmentation c (% Intensity in Brackets)	Identification
M7b	6.18	(−)-1 or rac-3	399.2/223.1 399.2/205.1	205.1241 (100), 223.1 (60), 136.0 (37), 203.1 (20), 110.0 (18), 177.1 (16), 83.0 (11), 207.1 (11), 162.0 (11), 82.0 (10), 116.0 (8), 163.1 (8), 190.1 (7), 124.0 (7)	Hydroxylation + Glucuronidation d
M8a	3.60	(+)-1 or rac-3	399.2/223.1 399.2/205.1	223.1 (100), 205.1 (21), 124.1 (6), 110.2 (6), 136.0 (6), 84.9 (4), 113.0 (4)
M8b	3.22	(−)-1 or rac-3	399.2/223.1 399.2/205.1	223.1 (100), 205.1 (27), 136.1 (16), 84.9 (9), 110.0 (8), 150.0 (6), 203.2 (6), 82.9 (6), 67.9 (4), 190.1 (4), 113.0 (3)

^a data for M7a, formed from (+)-1 or rac-3, correspond to those stated in Table 1; ^b Retention time (time/min); ^c parameters for data acquisition described in Section 4.7.; ^d for rac-3 glucuronidation only.