Table 2.
Anti-H. pylori, antitubercular and cytotoxic activities of Compounds 1–15 in µM.
| Compound | Anti-H. pylori (MIC) | Anti-TB (MIC) | Cytotoxic (IC50 ± SEM) | ||
|---|---|---|---|---|---|
| MCF-7 | HCT-116 | HepG2 | |||
| 1 | 4.39 | 0.54 | 24.6 ± 2.3 | 25.5 ± 3.3 | 19.8 ± 1.4 |
| 2 | NA | 16.00 | 1.2 ± 0.1 | 0.4 ± 0.1 | 1.1 ± 0.1 |
| 3 | 10.10 | 5.05 | NA | NA | NA |
| 4 | 9.11 | 1.12 | 25.9 ± 1.9 | 17.5 ± 1.3 | 24.7 ± 4.8 |
| 5 | 146.02 | 9.13 | 22.0 ± 0.4 | 15.2 ± 2.0 | 15.3 ± 1.1 |
| 6 | 8.78 | 4.39 | - | - | - |
| 7 | 20.23 | 5.05 | 1.6 ± 0.1 | 1.4 ± 0.05 | 1.6 ± 0.5 |
| 8 | 80.95 | 10.12 | 32.7 ± 3.2 | 34.5 ± 7.5 | 23.5 ± 1.8 |
| 9 | 77.73 | 19.42 | NA | NA | NA |
| 10 | 8.47 | 4.23 | 12.4 ± 0.9 | 2.9 ± 0.7 | 5.5 ± 0.9 |
| 11 | 263.71 | 16.47 | 55.6 ± 2.1 | 17.8 ± 1.9 | 20.1 ± 1.5 |
| 12 | 32.97 | 8.24 | 37.3 ± 5.5 | 22.8 ± 2.2 | 34.9 ± 6.1 |
| 13 | 16.03 | 8.02 | 54.2 ± 3.3 | 26.5 ± 1.1 | 26.6 ± 3.8 |
| 14 | 81.38 | 20.33 | NA | NA | NA |
| 15 | 33.97 | 16.97 | 34.9 ± 4.9 | 48.6 ± 7.2 | 27.3 ± 3.3 |
| isoniazid | ---- | 0.87 | ---- | ---- | ---- |
| clarithromycin | 1.31 | ---- | ---- | ---- | ---- |
| doxorubicin | ---- | ---- | 0.41 ± 0.1 | 0.11 ± 0.04 | 0.85 ± 0.1 |
NA: No activity within the range of concentration used; data are presented as the mean ± SD; n = 3.