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. 2018 Apr 10;23(4):864. doi: 10.3390/molecules23040864

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of the drugs on the endocytic index of the Leishmania (L.) amazonensis amastigotes in mice macrophages. Meglumine antimoniate (A) and epoxymethoxy-lawsone (B) were co-incubated in cultures of BALB/c mice macrophages infected with L. (L.) amazonensis for 24 h and 48 h. Control cultures (black bars) were treated with RPMI 1640 medium only or with 1% of DMSO, respectively. The results are expressed as the mean and standard deviation of three assays. All concentration points analyzed showed statistical significance from their respective controls: (*) p ≤ 0.042; (**) p ≤ 0.009; (***) p ≤ 0.0003).

Effects of the drugs on the endocytic index of the Leishmania (L.) amazonensis amastigotes in mice macrophages. Meglumine antimoniate (A) and epoxymethoxy-lawsone (B) were co-incubated in cultures of BALB/c mice macrophages infected with L. (L.) amazonensis for 24 h and 48 h. Control cultures (black bars) were treated with RPMI 1640 medium only or with 1% of DMSO, respectively. The results are expressed as the mean and standard deviation of three assays. All concentration points analyzed showed statistical significance from their respective controls: (*) p ≤ 0.042; (**) p ≤ 0.009; (***) p ≤ 0.0003).