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J1036 induces apoptosis in S. mansoni schistosomula in vitro. (A) Dose-dependent induction of apoptosis determined by dUTP nick end labeling (TUNEL) shown as the percentage of parasites positively labeled; (B) TUNEL staining of schistosomula treated with 100 µM J1036 for 3 days. Parasites were counterstained using 4′,6-Diamidino-2-Phenylindole (DAPI).
