Table 7.
Pharmacokinetic parameters of the fourteen alkaloids in male ICR mice after oral administration of Corydalis yanhusuo extract. (n = 8, mean ± SD).
| No. | Parameters | Cmax (ng/mL) | Tmax (min) | AUC0−t (ng min/mL) | AUC0−∞ (ng min/mL) | MRT0−t (min) | T1/2z (min) |
|---|---|---|---|---|---|---|---|
| 1 | Corydaline | 53.27 ± 23.9 | 11.88 ± 2.59 | 4213.67 ± 1053.77 | 4219.32 ± 1052.51 | 115.09 ± 16.58 | 129.76 ± 53.45 |
| 2 | Tetrahydroberberine | 36.00 ± 23.1 | 10.00 ± 2.67 | 2017.5 ± 625.79 | 2020.81 ± 626 | 86.64 ± 22.68 | 90.31 ± 29.54 |
| 3 | Tetrahydropalmatine | 196.8 ± 116.3 | 17.50 ± 8.02 | 23,339.78 ± 7008.07 | 23,532.54 ± 7028.61 | 111.04 ± 17.06 | 62.11 ± 28.68 |
| 4 | Tetrahydrocolumbamine | 29.45 ± 22.39 | 35.63 ± 11.16 | 5330.56 ± 1151.48 | 5629.85 ± 1260.27 | 142.33 ± 9.13 | 94.02 ± 42.89 |
| 5 | Tetrahydrocoptisine | 65.86 ± 27.11 | 10.63 ± 1.77 | 6399.24 ± 1272.69 | 6402.31 ± 1274.6 | 123.42 ± 17.29 | 82.19 ± 30.62 |
| 6 | Columbamine | 1.66 ± 1.01 | 10.00 ± 2.67 | 492.33 ± 155.03 | 513.41 ± 155.25 | 327.8 ± 92.90 | 346.25 ± 148.93 |
| 7 | Palmatine | 14.33 ± 11.83 | 15.00 ± 6.55 | 2122.38 ± 549.93 | 2394.48 ± 518.15 | 169.29 ± 26.40 | 130.94 ± 28.77 |
| 8 | Berberine | ND * | ND | ND | ND | ND | ND |
| 9 | Epiberberine | ND | ND | ND | ND | ND | ND |
| 10 | Coptisine | 18.73 ± 13.31 | 28.13 ± 9.61 | 8039.17 ± 1924.04 | 8917.46 ± 1825.53 | 387.9 ± 90.88 | 432.93 ± 209.37 |
| 11 | Jatrorrhizine | 1.78 ± 0.57 | 15.63 ± 6.23 | 449.51 ± 160.24 | 461.64 ± 152.08 | 246.78 ± 59.02 | 196.09 ± 90.99 |
| 12 | Dehydrocorydaline | 8.50 ± 6.57 | 11.88 ± 7.53 | 2185.27 ± 1137.06 | 2222.64 ± 1125.92 | 163.18 ± 77.61 | 90.71 ± 56.48 |
| 13 | Oxoglaucine | 32.73 ± 21.2 | 15.00 ± 7.07 | 4797.27 ± 329.42 | 4831.29 ± 336.64 | 232.27 ± 33.42 | 202.93 ± 50.20 |
| 14 | Protopine | 26.43 ± 24.22 | 21.25 ± 9.54 | 3025.95 ± 736.76 | 3075.23 ± 706.99 | 163.5 ± 21.94 | 318.76 ± 251.55 |
* ND = Not detected within the linear range.