Table 6.
Summary of kuraridin metabolites in rat plasma.
| Peak | tR | Experimental | Theoretical | Error | Formula [M − H]− | MS/MS Fragment | Identification/Reactions |
|---|---|---|---|---|---|---|---|
| Mass (m/z) | Mass (m/z) | (ppm) | |||||
| M1 | 6.74 | 789.2626 | 789.2612 | 1.82 | C38H45O18 | MS2[789]: 161.0235(100),613.2296(36),275.1656(33),437.1964(4) | Diglucuronidation |
| M2 | 7.26 | 789.2622 | 789.2612 | 1.36 | C38H45O18 | MS2[789]: 161.0235(100),613.2289(31),275.1659(31),437.1954(4) | Diglucuronidation |
| M3 | 9.91 | 789.2623 | 789.2612 | 1.51 | C38H45O18 | MS2[789]: 161.0235(100),275.1655(31),613.2299(28),437.1989(5) | Diglucuronidation |
| M4 | 11.87 | 789.2619 | 789.2612 | 0.97 | C38H45O18 | MS2[789]: 161.0235(100),789.2916(36),275.1658 (28),613.2286(16) | Diglucuronidation |
| M5 | 7.44 | 613.2299 | 613.2291 | 1.32 | C32H37O12 | MS2[613]: 161.0237(100),275.1653(41),437.1976(5) | Glucuronidation |
| M6 | 7.66 | 613.2302 | 613.2291 | 1.91 | C32H37O12 | MS2[613]: 161.0236(100),275.1659(28),137.0235(23),437.1969(5) | Glucuronidation |
| M7 | 9.48 | 613.2302 | 613.2291 | 1.91 | C32H37O12 | MS2[613]: 161.0237(100),275.1659(26),151.0391(17) | Glucuronidation |
| M8 | 12.40 | 613.2299 | 613.2291 | 1.32 | C32H37O12 | MS2[613]: 161.0236(100),275.1653(13),151.0394(13) | Glucuronidation |
| M9 | 12.63 | 613.2296 | 613.2291 | 0.82 | C32H37O12 | MS2[613]: 161.0237(100),275.1658(21),137.0236(6) | Glucuronidation |
| M10 | 15.02 | 613.2297 | 613.2291 | 1.23 | C32H37O12 | MS2[613]: 161.0236(100),275.1657(39),437.1979(15) | Glucuronidation |
| M11 | 16.85 | 613.2300 | 613.2291 | 1.61 | C32H37O12 | MS2[613]: 161.0236(100),275.1658(23),437.1980(7) | Glucuronidation |
| M12 | 17.31 | 613.2301 | 613.2291 | 1.71 | C32H37O12 | MS2[613]: 161.0237(100),275.1658(18),437.1980(14) | Glucuronidation |
| M13 | 17.64 | 613.2302 | 613.2291 | 1.91 | C32H37O12 | MS2[613]:161.0237(100),275.1662(19),437.1980(11) | Glucuronidation |
| M14 | 18.08 | 613.2301 | 613.2291 | 1.71 | C32H37O12 | MS2[613]: 161.0236(100),275.1658(26),151.0393(13),437.1979(5) | Glucuronidation |
| M15 | 7.78 | 453.1926 | 453.1919 | 1.58 | C26H29O7 | MS2[453]: 161.0237(100),151.0392(36),291.1607(16) | Hydroxylation |
| M16 | 7.94 | 453.1925 | 453.1919 | 1.38 | C26H29O7 | MS2[453]: 161.0236(100),151.0392(20),291.1609(15),137.0235(13) | Hydroxylation |
| M17 | 8.40 | 453.1928 | 453.1919 | 1.93 | C26H29O7 | MS2[453]: 161.0236(100),137.0236(36),291.1610(25),151.0393(13) | Hydroxylation |
| M18 | 12.11 | 453.1924 | 453.1919 | 1.24 | C26H29O7 | MS2[453]: 149.0237(100),177.0187(96),275.1658(63),137.0234(49),151.0394(38) | Kushenol N |
| M19 | 14.37 | 437.1975 | 437.19696 | 1.19 | C26H29O6 | MS2[437]: 161.0236(100),275.1656(33),137.0235(24),151.0392(14) | Kurarinone |
| M0 | 20.51 | 437.1982 | 437.19696 | 2.72 | C26H29O6 | MS2[437]: 161.0237(100),275.1657(39),137.0235(31),151.0393(20) | Kuraridin |