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A schematic of the SABRE-SHEATH hyperpolarization process of metronidazole-15N2-13C2 using transfer of spin order from para-H2 on an Ir-IMes hexacoordinate complex.23, 26 SABRE-SHEATH is accomplished via spin-spin couplings between para-H2-derived hydride protons and nuclear spins of the equatorial exchangeable ligands. The axial ligands are not exchangeable.
