Skip to main content
. Author manuscript; available in PMC: 2018 Jun 25.
Published in final edited form as: AIMS Biophys. 2017 Aug 21;4(3):491–527. doi: 10.3934/biophy.2017.3.491

Figure 3.

Figure 3

(A) Receptor deactivation is mediated by the RGS family of proteins. RGS alters the conformation of Gα-GTP complex making it a better hydrolase, which accelerates the hydrolysis of GTP to GDP. (B) GPCR desensitization through internalization occurs when GRK phosphorylates the activated receptor promoting β-arresting binding, which sterically hinders receptor-G protein interaction. The receptor is either degraded or recycled back to the cell surface. Figure 3A was adapted from Neubig, et al. [191] and 3B was adapted from Pierce, et al. [4].