Figure 6.
Superpositions of GPCR represented as thin ribbon structures with ligands as space-filling atoms colored accordingly by antagonists as green, agonists as fuchsia, and negative allosteric modulators as orange. (A) Structures of 29 individual class A GPCR. (B) Structures of 3 class B GPCR. (C) Structures of 4 class C GPCR. (D) Structures of 7 class F GPCR. Class A GPCR: Rho (1F88), ADRB1 (2VT4), ADRB2 (2RH1), H1R (3RZE), D3R (3PBL), 5-HT1B (4IAQ), 5-HT2B (4IB4), M1R (5CXV), M2R (3UON), M3R (4DAJ), M4R (5DSG), A2AR (2YDO), S1P1 (3V2W), LPA1 (4Z34), CB1 (5TGZ), NTSR1 (3ZEV), OX1 (4ZJ8), OX2 (4S0V), CCR4 (3ODU), CCR5 (4MBS), CCR9 (5LWE), NOP (4EA3), κ-OR (4DJH), μ-OR (4DKL), δ-OR (4EJ4), AT1R (4YAY), P2Y1 (4XNW), P2Y12 (4NTJ), PAR1 (3VW7). Class B GPCR: GCGR (5EE7), CRF1R (4K5Y, 4Z9G). Class C GPCR: mGlu1 (4OR2, 5CGC, 5CGD), mGlu5 (4OO9) Class F GPCR: SMO (4JKV, 4N4W, 4OR9, 4QIM, 4QIN, 5L7D, 5L7I).