Table 1.

A comprehensive list of GPCR crystal structures according to date deposited into the Protein Data Bank as of April 19, 2017.

GPCR Crystal Structures
Individual Receptors	Family	Class/Subclass	Species	Receptor	PDB [46] ID	Resolution (Å)	Date Deposited
1	Rhodopsin	Class Aα	Bovine	Rho	1F88 [25]	2.80	6/29/00
2	Rhodopsin	Class Aα	Bovine	Rho	1HZX [94]	2.80	1/26/01
3	Rhodopsin	Class Aα	Bovine	Rho	1JFP [95]	Solution NMR	6/21/01
4	Rhodopsin	Class Aα	Bovine	Rho	1L9H [96]	2.60	3/23/02
5	Rhodopsin	Class Aα	Bovine	Rho	1LN6 [97]	Solution NMR	5/3/02
6	Rhodopsin	Class Aα	Bovine	Rho	1GZM [98]	2.65	5/24/02
7	Rhodopsin	Class Aα	Bovine	Rho	1U19 [99]	2.20	7/15/04
8	Rhodopsin	Class Aα	Bovine	Rho	2G87 [100]	2.60	3/2/06
9	Rhodopsin	Class Aα	Bovine	Rho	2HPY [101]	2.80	7/18/06
10	Rhodopsin	Class Aα	Bovine	Rho	2I35 [102]	3.80	8/17/06
11	Rhodopsin	Class Aα	Bovine	Rho	2I36 [102]	4.10	8/17/06
12	Rhodopsin	Class Aα	Bovine	Rho	2I37 [102]	4.15	8/17/06
13	Rhodopsin	Class Aα	Bovine	Rho	2J4Y [103]	3.40	9/7/06
14	Rhodopsin	Class Aα	Bovine	Rho	2PED [104]	2.95	4/2/07
15	Rhodopsin	Class Aα	Bovine	Rho	3C9L [105]	2.65	2/16/08
16	Rhodopsin	Class Aα	Bovine	Rho	3C9M [105]	3.40	2/16/08
17	Rhodopsin	Class Aα	Bovine	Rho	3CAP [73]	2.90	2/20/08
18	Rhodopsin	Class Aα	Bovine	Rho	3DQB [106]	3.20	7/9/08
19	Rhodopsin	Class Aα	Bovine	Rho	2X72 [107]	3.00	2/22/10
20	Rhodopsin	Class Aα	Bovine	Rho	3OAX[108]	2.60	8/5/10
21	Rhodopsin	Class Aα	Bovine	Rho	3PQR [109]	2.85	11/26/10
22	Rhodopsin	Class Aα	Bovine	Rho	3PXO [109]	3.00	12/10/10
23	Rhodopsin	Class Aα	Bovine	Rho	4A4M [110]	3.30	10/17/11
24	Rhodopsin	Class Aα	Bovine	Rho	4J4Q [111]	2.65	2/7/13
25	Rhodopsin	Class Aα	Bovine	Rho	4BEY [112]	2.90	3/12/13
26	Rhodopsin	Class Aα	Bovine	Rho	4BEZ [112]	3.30	3/12/13
27	Rhodopsin	Class Aα	Bovine	Rho	4PXF [113]	2.75	3/23/14
28	Rhodopsin	Class Aα	Bovine	Rho	4X1H [114]	2.29	11/24/14
29	Rhodopsin	Class Aα	Human	Rho	4ZWJ [115]	3.30	5/19/15
30	Rhodopsin	Class Aα	Bovine	Rho	5DYS [116]	2.30	9/25/15
31	Rhodopsin	Class Aα	Bovine	Rho	5EN0 [116]	2.81	11/8/15
32	Rhodopsin	Class Aα	Bovine	Rho	5TE3 [117]	2.70	9/20/16
33	Rhodopsin	Class Aα	Bovine	Rho	5TE5 [117]	4.01	9/21/16
34	Rhodopsin	Class Aα	Turkey	ADRB1	2VT4 [72]	2.70	5/9/08
35	Rhodopsin	Class Aα	Turkey	ADRB1	2Y00 [118]	2.50	11/30/10
36	Rhodopsin	Class Aα	Turkey	ADRB1	2Y01[118]	2.60	11/30/10
37	Rhodopsin	Class Aα	Turkey	ADRB1	2Y02 [118]	2.60	11/30/10
38	Rhodopsin	Class Aα	Turkey	ADRB1	2Y03 [118]	2.85	11/30/10
39	Rhodopsin	Class Aα	Turkey	ADRB1	2Y04 [118]	3.05	11/30/10
40	Rhodopsin	Class Aα	Turkey	ADRB1	2YCW [74]	3.00	3/17/11
41	Rhodopsin	Class Aα	Turkey	ADRB1	2YCX [74]	3.25	3/17/11
42	Rhodopsin	Class Aα	Turkey	ADRB1	2YCY [74]	3.15	3/17/11
43	Rhodopsin	Class Aα	Turkey	ADRB1	2YCZ [74]	3.65	3/17/11
44	Rhodopsin	Class Aα	Turkey	ADRB1	3ZPQ [119]	2.80	3/1/13
45	Rhodopsin	Class Aα	Turkey	ADRB1	3ZPR [119]	2.70	3/1/13
46	Rhodopsin	Class Aα	Turkey	ADRB1	4AMI [120]	3.20	3/11/12
47	Rhodopsin	Class Aα	Turkey	ADRB1	4AMJ [120]	2.30	3/12/12
48	Rhodopsin	Class Aα	Turkey	ADRB1	4BVN [69]	2.10	6/26/13
49	Rhodopsin	Class Aα	Turkey	ADRB1	4GPO [121]	3.50	8/21/12
50	Rhodopsin	Class Aα	Turkey	ADRB1	5A8E [122]	2.40	7/15/15
51	Rhodopsin	Class Aα	Turkey	ADRB1	5F8U [123]	3.35	12/9/15
52	Rhodopsin	Class Aα	Human	ADRB2	2R4R [27]	3.40	8/31/07
53	Rhodopsin	Class Aα	Human	ADRB2	2R4S [27]	3.40	8/31/07
54	Rhodopsin	Class Aα	Human	ADRB2	2RH1 [26]	2.40	10/5/07
55	Rhodopsin	Class Aα	Human	ADRB2	3D4S [124]	2.80	5/14/08
56	Rhodopsin	Class Aα	Human	ADRB2	3KJ6 [125]	3.40	11/2/09
57	Rhodopsin	Class Aα	Human	ADRB2	3NY8 [126]	2.84	7/14/10
58	Rhodopsin	Class Aα	Human	ADRB2	3NY9 [126]	2.84	7/14/10
59	Rhodopsin	Class Aα	Human	ADRB2	3NYA [126]	3.16	7/14/10
60	Rhodopsin	Class Aα	Human	ADRB2	3P0G [127]	3.50	9/28/10
61	Rhodopsin	Class Aα	Human	ADRB2	3PDS [128]	3.50	10/24/10
62	Rhodopsin	Class Aα	Human	ADRB2	3SN6 [18]	3.20	6/28/11
63	Rhodopsin	Class Aα	Human	ADRB2	4GBR [129]	3.99	7/27/12
64	Rhodopsin	Class Aα	Human	ADRB2	4LDE [130]	2.79	6/24/13
65	Rhodopsin	Class Aα	Human	ADRB2	4LDL [130]	3.10	6/24/13
66	Rhodopsin	Class Aα	Human	ADRB2	4LDO [130]	3.20	6/24/13
67	Rhodopsin	Class Aα	Human	ADRB2	4QKX [131]	3.30	6/10/14
68	Rhodopsin	Class Aα	Human	ADRB2	5D5A [132]	2.48	8/10/15
69	Rhodopsin	Class Aα	Human	ADRB2	5D5B [132]	3.80	8/10/15
70	Rhodopsin	Class Aα	Human	ADRB2	5D6L [133]	3.20	8/12/15
71	Rhodopsin	Class Aα	Human	ADRB2	5JQH [134]	3.20	5/5/16
72	Rhodopsin	Class Aα	Human	H1R	3RZE [135]	3.10	5/11/11
73	Rhodopsin	Class Aα	Human	D3R	3PBL [6]	2.89	10/20/10
74	Rhodopsin	Class Aα	Human	5-HT1B	4IAQ [136]	2.80	12/7/12
75	Rhodopsin	Class Aα	Human	5-HT1B	4IAR [136]	2.70	12/7/12
76	Rhodopsin	Class Aα	Human	5-HT2B	4IB4 [137]	2.70	12/7/12
77	Rhodopsin	Class Aα	Human	5-HT2B	4NC3 [138]	2.80	10/23/13
78	Rhodopsin	Class Aα	Human	5-HT2B	5TVN [139]	2.90	11/9/16
79	Rhodopsin	Class Aα	Human	M1R	5CXV [140]	2.70	7/29/15
80	Rhodopsin	Class Aα	Human	M2R	3UON [141]	3.00	11/16/11
81	Rhodopsin	Class Aα	Human	M2R	4MQS [142]	3.50	9/16/13
82	Rhodopsin	Class Aα	Human	M2R	4MQT [142]	3.70	9/16/13
83	Rhodopsin	Class Aα	Rat	M3R	4DAJ [143]	3.40	1/12/12
84	Rhodopsin	Class Aα	Rat	M3R	4U14 [144]	3.57	7/15/14
85	Rhodopsin	Class Aα	Rat	M3R	4U15 [144]	2.80	7/15/14
86	Rhodopsin	Class Aα	Rat	M3R	4U16 [144]	3.70	7/15/14
87	Rhodopsin	Class Aα	Human	M4R	5DSG [140]	2.60	9/17/15
88	Rhodopsin	Class Aα	Human	A1AR	5UEN [145]	3.20	1/3/17
89	Rhodopsin	Class Aα	Human	A2AR	3EML [37]	2.60	9/24/08
90	Rhodopsin	Class Aα	Human	A2AR	3PWH [146]	3.30	12/8/10
91	Rhodopsin	Class Aα	Human	A2AR	3QAK [68]	2.71	1/11/11
92	Rhodopsin	Class Aα	Human	A2AR	2YDO [147]	3.00	3/23/11
93	Rhodopsin	Class Aα	Human	A2AR	2YDV [147]	2.60	3/24/11
94	Rhodopsin	Class Aα	Human	A2AR	3REY [146]	3.31	4/5/11
95	Rhodopsin	Class Aα	Human	A2AR	3RFM [146]	3.60	4/6/11
96	Rhodopsin	Class Aα	Human	A2AR	3VG9 [148]	2.70	8/4/11
97	Rhodopsin	Class Aα	Human	A2AR	3VGA [148]	3.10	8/4/11
98	Rhodopsin	Class Aα	Human	A2AR	3UZA [149]	3.27	12/7/11
99	Rhodopsin	Class Aα	Human	A2AR	3UZC [149]	3.34	12/7/11
100	Rhodopsin	Class Aα	Human	A2AR	4EIY [66]	1.80	4/6/12
101	Rhodopsin	Class Aα	Human	A2AR	4UG2 [150]	2.60	3/21/15
102	Rhodopsin	Class Aα	Human	A2AR	4UHR [150]	2.60	3/25/15
103	Rhodopsin	Class Aα	Human	A2AR	5IU4 [151]	1.72	3/17/16
104	Rhodopsin	Class Aα	Human	A2AR	5IU7 [151]	1.90	3/17/16
105	Rhodopsin	Class Aα	Human	A2AR	5IU8 [151]	2.00	3/17/16
106	Rhodopsin	Class Aα	Human	A2AR	5IUA [151]	2.20	3/17/16
107	Rhodopsin	Class Aα	Human	A2AR	5IUB [151]	2.10	3/17/16
108	Rhodopsin	Class Aα	Human	A2AR	5K2A [152]	2.50	5/18/16
109	Rhodopsin	Class Aα	Human	A2AR	5K2B [152]	2.50	5/18/16
110	Rhodopsin	Class Aα	Human	A2AR	5K2C [152]	1.90	5/18/16
111	Rhodopsin	Class Aα	Human	A2AR	5K2D [152]	1.90	5/18/16
112	Rhodopsin	Class Aα	Human	A2AR	5G53 [153]	3.40	5/19/16
113	Rhodopsin	Class Aα	Human	A2AR	5UIG [154]	3.50	1/13/17
114	Rhodopsin	Class Aα	Human	S1P1	3V2W [155]	3.35	12/12/11
115	Rhodopsin	Class Aα	Human	S1P1	3V2Y [155]	2.80	12/12/11
116	Rhodopsin	Class Aα	Human	LPA1	4Z34 [156]	3.00	3/30/15
117	Rhodopsin	Class Aα	Human	LPA1	4Z35 [156]	2.90	3/30/15
118	Rhodopsin	Class Aα	Human	LPA1	4Z36 [156]	2.90	3/30/15
119	Rhodopsin	Class Aα	Human	CB1	5TGZ [157]	2.80	9/28/16
120	Rhodopsin	Class Aα	Human	CB1	5U09 [158]	2.60	11/23/16
121	Rhodopsin	Class Aβ	Rat	NTSR1	4GRV [159]	2.80	8/27/12
122	Rhodopsin	Class Aβ	Rat	NTSR1	3ZEV [160]	3.00	12/7/12
123	Rhodopsin	Class Aβ	Rat	NTSR1	4BUO [160]	2.75	6/21/13
124	Rhodopsin	Class Aβ	Rat	NTSR1	4BV0 [160]	3.10	6/24/13
125	Rhodopsin	Class Aβ	Rat	NTSR1	4BWB [160]	3.57	7/1/13
126	Rhodopsin	Class Aβ	Rat	NTSR1	4XEE [161]	2.90	12/23/14
127	Rhodopsin	Class Aβ	Rat	NTSR1	4XES [161]	2.60	12/24/14
128	Rhodopsin	Class Aβ	Rat	NTSR1	5T04 [162]	3.30	8/16/16
129	Rhodopsin	Class Aβ	Human	OX1	4ZJ8 [41]	2.75	4/29/15
130	Rhodopsin	Class Aβ	Human	OX1	4ZJC [41]	2.83	4/29/15
131	Rhodopsin	Class Aβ	Human	OX2	4S0V [163]	2.50	1/6/15
132	Rhodopsin	Class Aβ	Human	TACR1	2KS9 [164]	Solution NMR	12/31/09
133	Rhodopsin	Class Aβ	Human	TACR1	2KSA [164]	Solution NMR	12/31/09
134	Rhodopsin	Class Aβ	Human	TACR1	2KSB [164]	Solution NMR	12/31/09
135	Rhodopsin	Class Aβ	Human	ET-B	5GLI [165]	2.5	7/11/16
136	Rhodopsin	Class Aβ	Human	ET-B	5GLH [165]	2.8	7/11/16
137	Rhodopsin	Class Aγ	Human	CXCR1	2LNL [166]	Solid-State NMR	12/31/11
138	Rhodopsin	Class Aγ	Human	CCR2	5T1A [167]	2.81	8/18/16
139	Rhodopsin	Class Aγ	Human	CXCR4	3ODU [168]	2.50	8/11/10
140	Rhodopsin	Class Aγ	Human	CXCR4	3OE0 [168]	2.90	8/12/10
141	Rhodopsin	Class Aγ	Human	CXCR4	3OE6 [168]	3.20	8/12/10
142	Rhodopsin	Class Aγ	Human	CXCR4	3OE8 [168]	3.10	8/12/10
143	Rhodopsin	Class Aγ	Human	CXCR4	3OE9 [168]	3.10	8/12/10
144	Rhodopsin	Class Aγ	Human	CXCR4	4RWS [169]	3.10	12/5/14
145	Rhodopsin	Class Aγ	Human	CCR5	4MBS [170]	2.71	8/19/13
146	Rhodopsin	Class Aγ	Human	CCR9	5LWE [171]	2.80	9/16/16
147	Rhodopsin	Class Aγ	Human	NOP	4EA3 [39]	3.01	3/22/12
148	Rhodopsin	Class Aγ	Human	NOP	5DHG [172]	3.00	8/30/15
149	Rhodopsin	Class Aγ	Human	NOP	5DHH [172]	3.00	8/31/15
150	Rhodopsin	Class Aγ	Human	κ-OR	4DJH [173]	2.90	2/1/12
151	Rhodopsin	Class Aγ	Mouse	μ-OR	4DKL [174]	2.80	2/3/12
152	Rhodopsin	Class Aγ	Mouse	μ-OR	5C1M[175]	2.10	6/15/15
153	Rhodopsin	Class Aγ	Mouse	δ-OR	4EJ4 [176]	3.40	4/6/12
154	Rhodopsin	Class Aγ	Human	δ-OR	4N6H [70]	1.80	10/12/13
155	Rhodopsin	Class Aγ	Human	δ-OR	4RWA [177]	3.28	12/1/14
156	Rhodopsin	Class Aγ	Human	δ-OR	4RWD [177]	2.70	12/2/14
157	Rhodopsin	Class Aγ	Human	AT1R	4YAY [178]	2.90	2/18/15
158	Rhodopsin	Class Aγ	Human	AT1R	4ZUD [179]	2.80	5/15/15
159	Rhodopsin	Class Aγ	Human	AT2R	5UNF [180]	2.80	1/30/17
160	Rhodopsin	Class Aγ	Human	AT2R	5UNG [180]	2.80	1/30/17
161	Rhodopsin	Class Aγ	Human	AT2R	5UNH [180]	2.90	1/30/17
162	Rhodopsin	Class Aγ	HHV-5	HHV-5 US28	4XT1 [181]	2.89	1/22/15
163	Rhodopsin	Class Aγ	HHV-5	HHV-5 US28	4XT3 [181]	3.80	1/22/15
164	Rhodopsin	Class Aδ	Human	P2Y1	4XNW [182]	2.70	1/16/15
165	Rhodopsin	Class Aδ	Human	P2Y1	4XNV [182]	2.20	1/16/15
166	Rhodopsin	Class Aδ	Human	P2Y12	4NTJ [42]	2.62	12/2/13
167	Rhodopsin	Class Aδ	Human	P2Y12	4PXZ [183]	2.50	3/25/14
168	Rhodopsin	Class Aδ	Human	P2Y12	4PY0 [183]	3.10	3/25/14
169	Rhodopsin	Class Aδ	Human	PAR1	3VW7 [71]	2.20	8/7/12
170	Rhodopsin	Class Aδ	Human	FFAR1	4PHU [184]	2.33	5/7/14
171	Secretin	Class B	Human	GCGR	4L6R [185]	3.30	6/12/13
172	Secretin	Class B	Human	GCGR	5EE7 [78]	2.50	10/22/15
173	Secretin	Class B	Human	CRF1R	4K5Y [186]	2.98	4/15/13
174	Secretin	Class B	Human	CRF1R	4Z9G [187]	3.18	4/10/15
175	Glutamate	Class C	Human	mGlu1	4OR2 [188]	2.80	2/10/14
176	Glutamate	Class C	Human	mGlu5	4OO9 [38]	2.60	1/31/14
177	Glutamate	Class C	Human	mGlu5	5CGC [189]	3.10	7/9/15
178	Glutamate	Class C	Human	mGlu5	5CGD [189]	2.60	7/9/15
179	Frizzled/Taste2	Class F	Human	SMO	4JKV [40]	2.45	3/11/13
180	Frizzled/Taste2	Class F	Human	SMO	4N4W [190]	2.80	10/8/13
181	Frizzled/Taste2	Class F	Human	SMO	4O9R [131]	3.20	1/2/14
182	Frizzled/Taste2	Class F	Human	SMO	4QIM [190]	2.61	5/31/14
183	Frizzled/Taste2	Class F	Human	SMO	4QIN [190]	2.60	5/31/14
184	Frizzled/Taste2	Class F	Human	SMO	5L7D [93]	3.20	6/3/16
185	Frizzled/Taste2	Class F	Human	SMO	5L7I [93]	3.30	6/3/16