1 |
1F88 [25] |
Class Aα |
Rho |
11-cis-Retinal |
|
2 |
1GZM [98] |
Class Aα |
Rho |
11-cis-Retinal |
|
3 |
1HZX [94] |
Class Aα |
Rho |
11-cis-Retinal |
|
4 |
1JFP [95] |
Class Aα |
Rho |
all-trans-Retinal |
|
5 |
1L9H [96] |
Class Aα |
Rho |
11-cis-Retinal |
|
6 |
1LN6 [97] |
Class Aα |
Rho |
all-trans-Retinal |
|
7 |
1U19 [99] |
Class Aα |
Rho |
11-cis-Retinal |
|
8 |
2G87 [100] |
Class Aα |
Rho |
all-trans-Retinal |
|
9 |
2HPY [101] |
Class Aα |
Rho |
all-trans-Retinal |
|
10 |
2I35 [102] |
Class Aα |
Rho |
11-cis-Retinal |
|
11 |
2J4Y [103] |
Class Aα |
Rho |
11-cis-Retinal |
|
12 |
2PED [104] |
Class Aα |
Rho |
9-cis-Retinal |
|
13 |
2X72 [107] |
Class Aα |
Rho |
11-cis-Retinal |
|
14 |
3C9L [105] |
Class Aα |
Rho |
11-cis-Retinal |
|
15 |
3C9M [105] |
Class Aα |
Rho |
11-cis-Retinal |
|
16 |
3OAX [108] |
Class Aα |
Rho |
11-cis-Retinal |
|
17 |
3PQR [109] |
Class Aα |
Rho |
all-trans-Retinal |
|
18 |
3PXO [109] |
Class Aα |
Rho |
all-trans-Retinal |
|
19 |
4A4M [110] |
Class Aα |
Rho |
all-trans-Retinal |
|
20 |
5DYS [116] |
Class Aα |
Rho |
all-trans-Retinal |
|
21 |
5EN0 [116] |
Class Aα |
Rho |
all-trans-Retinal |
|
22 |
5TE5 [117] |
Class Aα |
Rho |
(2E)-{(4E)-4-[(3E)-4-(2,6,6-trimethylcyclohex- 1-en-1-yl)but-3-en-2-ylidene]cyclohex-2-en- 1-ylidene}acetaldehyde |
|
23 |
4J4Q [111] |
Class Aα |
Rho |
B-Octylglucoside |
Agonist-stabilized active receptor conformation |
24 |
2VT4 [72] |
Class Aα |
ADRB1
|
Cyanopindolol |
Antagonist |
25 |
2Y00 [118] |
Class Aα |
ADRB1
|
Dobutamine |
Partial Agonist |
26 |
2Y01 [118] |
Class Aα |
ADRB1
|
Dobutamine |
Partial Agonist |
27 |
2Y02 [118] |
Class Aα |
ADRB1
|
Carmoterol |
Agonist |
28 |
2Y03 [118] |
Class Aα |
ADRB1
|
Isoprenaline |
Agonist |
29 |
2Y04 [118] |
Class Aα |
ADRB1
|
Salbutamol |
Partial Agonist |
30 |
2YCW [74] |
Class Aα |
ADRB1
|
Carazolol |
Antagonist |
31 |
2YCX [74] |
Class Aα |
ADRB1
|
Cyanopindolol |
Antagonist |
32 |
2YCY [74] |
Class Aα |
ADRB1
|
Cyanopindolol |
Antagonist |
33 |
2YCZ [74] |
Class Aα |
ADRB1
|
Iodocyanopindolol |
Antagonist |
34 |
3ZPQ [119] |
Class Aα |
ADRB1
|
4-(Piperazin-1- yl)-1H-indole |
Antagonist |
35 |
3ZPR [119] |
Class Aα |
ADRB1
|
4-Methyl-2-(piperazin-1-yl)quinoline |
Antagonist |
36 |
4AMI [120] |
Class Aα |
ADRB1
|
Bucindolol |
Agonist |
37 |
4AMJ [120] |
Class Aα |
ADRB1
|
Carvedilol |
Agonist |
38 |
4BVN [69] |
Class Aα |
ADRB1
|
Cyanopindolol |
Antagonist |
39 |
5A8E [122] |
Class Aα |
ADRB1
|
7-methylcyanopindolol |
Agonist |
40 |
5F8U [123] |
Class Aα |
ADRB1
|
4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile |
Antagonist |
41 |
2RH1 [26] |
Class Aα |
ADRB2
|
Carazolol |
Antagonist |
42 |
3D4S [124] |
Class Aα |
ADRB2
|
Timolol maleate |
Antagonist |
43 |
3NY8 [126] |
Class Aα |
ADRB2
|
ICI 118,551 |
Antagonist |
44 |
3NY9 [126] |
Class Aα |
ADRB2
|
Ethyl 4-({(2S)-2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)- 3-methyl-1-benzofuran-2-carboxylate |
Antagonist |
45 |
3NYA [126] |
Class Aα |
ADRB2
|
Alprenolol |
Antagonist |
46 |
3P0G [127] |
Class Aα |
ADRB2
|
BI 167107 |
Agonist |
47 |
3PDS [128] |
Class Aα |
ADRB2
|
FAUC50 |
Agonist |
48 |
3SN6 [18] |
Class Aα |
ADRB2
|
BI 167107 |
Agonist |
49 |
4GBR [129] |
Class Aα |
ADRB2
|
BI 167107 |
Agonist |
50 |
4LDE [130] |
Class Aα |
ADRB2
|
BI 167107 |
Agonist |
51 |
4LDL [130] |
Class Aα |
ADRB2
|
Hydroxybenzyl isoproterenol |
Agonist |
52 |
4LDO [130] |
Class Aα |
ADRB2
|
Epinephrine |
Agonist |
53 |
4QKX [131] |
Class Aα |
ADRB2
|
FAUC37 |
Agonst |
54 |
5D5A [132] |
Class Aα |
ADRB2
|
Carazolol |
Antagonist |
55 |
5D5B [132] |
Class Aα |
ADRB2
|
Carazolol |
Antagonist |
56 |
5D6L [133] |
Class Aα |
ADRB2
|
Carazolol |
Antagonist |
57 |
5JQH [134] |
Class Aα |
ADRB2
|
Carazolol |
Antagonist |
58 |
3RZE [135] |
Class Aα |
H1R |
Doxepin (E/Z) |
Antagonist |
59 |
3PBL [6] |
Class Aα |
D3R |
Eticlopride |
Antagonist |
60 |
4IAQ [136] |
Class Aα |
5-HT1B
|
Dihydroergotamine |
Agonist |
61 |
4IAR [136] |
Class Aα |
5-HT1B
|
Ergotamine |
Agonist |
62 |
4IB4 [137] |
Class Aα |
5-HT2B
|
Ergotamine |
Agonist |
63 |
4NC3 [138] |
Class Aα |
5-HT2B
|
Ergotamine |
Agonist |
64 |
5TVN [139] |
Class Aα |
5-HT2B
|
(8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline- 8-carboxamide |
Agonist |
65 |
5CXV [140] |
Class Aα |
M1R |
Tiotropium |
Antagonist |
66 |
3UON [141] |
Class Aα |
M2R |
3-quinuclidinyl-benzilate |
Antagonist |
67 |
4MQS [142] |
Class Aα |
M2R |
Iperoxo |
Agonist |
68 |
4MQT [142] |
Class Aα |
M2R |
Iperoxo/LY2119620 |
Agonist/Allosteric modulator |
69 |
4DAJ [143] |
Class Aα |
M3R |
Tiotropium |
Antagonist |
70 |
4U14 [144] |
Class Aα |
M3R |
Tiotropium |
Antagonist |
71 |
4U15 [144] |
Class Aα |
M3R |
Tiotropium |
Antagonist |
72 |
4U16 [144] |
Class Aα |
M3R |
N-methyl scopolamine |
Antagonist |
73 |
5DSG [140] |
Class Aα |
M4R |
Tiotropium |
Antagonist |
74 |
5UEN [145] |
Class Aα |
A1AR |
DU172 |
Antagonist |
75 |
2YDO [147] |
Class Aα |
A2AR |
Adensoine |
Agonist |
76 |
2YDV [147] |
Class Aα |
A2AR |
NECA |
Agonist |
77 |
3EML [37] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
78 |
3PWH [146] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
79 |
3QAK [68] |
Class Aα |
A2AR |
UK-432097 |
Agonist |
80 |
3REY [146] |
Class Aα |
A2AR |
XAC |
Antagonist |
81 |
3RFM [146] |
Class Aα |
A2AR |
Caffeine |
Antagonist |
82 |
3UZA [149] |
Class Aα |
A2AR |
6-(2,6-Dimethylpyridin-4-yl)-5-phenyl-1,2,4-triazin-3-amine |
Antagonist |
83 |
3UZC [149] |
Class Aα |
A2AR |
4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol |
Antagonist |
84 |
3VG9 [148] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
85 |
3VGA [148] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
86 |
4EIY [66] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
87 |
4UG2 [150] |
Class Aα |
A2AR |
CGS21680 |
Agonist |
88 |
4UHR [150] |
Class Aα |
A2AR |
CGS21680 |
Agonist |
89 |
5G53 [153] |
Class Aα |
A2AR |
DB03719 |
Agonist |
90 |
5IU4 [151] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
91 |
5IU7 [151] |
Class Aα |
A2AR |
Compound 12c |
Antagonist |
92 |
5IU8 [151] |
Class Aα |
A2AR |
Compound 12f |
Antagonist |
93 |
5IUA [151] |
Class Aα |
A2AR |
Compound 12b |
Antagonist |
94 |
5IUB [151] |
Class Aα |
A2AR |
Compound 12x |
Antagonist |
95 |
5K2A [152] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
96 |
5K2B [152] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
97 |
5K2C [152] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
98 |
5K2D [152] |
Class Aα |
A2AR |
ZM241385 |
Antagonist |
99 |
5UIG [154] |
Class Aα |
A2AR |
5-amino-N-[(2-methoxyphenyl)methyl]-2-(3- methylphenyl)-2H-1,2,3-triazole-4-carboximidamide |
Angatonist |
100 |
3V2W [155] |
Class Aα |
S1P1
|
ML056 |
Antagonist |
101 |
3V2Y [155] |
Class Aα |
S1P1
|
ML056 |
Antagonist |
102 |
4Z34 [156] |
Class Aα |
LPA1
|
ONO9780307 |
Antagonist |
103 |
4Z35 [156] |
Class Aα |
LPA1
|
ONO-9910539 |
Antagonist |
104 |
4Z36 [156] |
Class Aα |
LPA1
|
ONO-3080573 |
Antagonist |
105 |
5TGZ [157] |
Class Aα |
CB1
|
AM6538 |
Antagonist |
106 |
5U09 [158] |
Class Aα |
CB1
|
Taranabant |
Antagonist |
107 |
3ZEV [160] |
Class Aβ |
NTSR1
|
Neurotensin |
Agonist |
108 |
4BUO [160] |
Class Aβ |
NTSR1
|
Neurotensin |
Agonist |
109 |
4BV0 [160] |
Class Aβ |
NTSR1
|
Neurotensin |
Agonist |
110 |
4BWB [160] |
Class Aβ |
NTSR1
|
Neurotensin |
Agonist |
111 |
4GRV [159] |
Class Aβ |
NTSR1
|
Neurotensin |
Agonist |
112 |
4XEE [161] |
Class Aβ |
NTSR1
|
Neurotensin |
Agonist |
113 |
4XES [161] |
Class Aβ |
NTSR1
|
Neurotensin |
Agonist |
114 |
5T04 [162] |
Class Aβ |
NTSR1
|
Neurotensin |
Agonist |
115 |
4ZJ8 [41] |
Class Aβ |
OX1
|
Suvorexant |
Dual Antagonist |
116 |
4ZJC [41] |
Class Aβ |
OX1
|
SB-674042 |
Antagonist |
117 |
4S0V [163] |
Class Aβ |
OX2
|
Suvorexant |
Dual Antagonist |
118 |
5GLH [165] |
Class Aβ |
ET-B |
Endothelin-1 |
Agonist |
119 |
5T1A [167] |
Class Aγ |
CCR2 |
BMS-681/CCR2-RA-[R] |
Orthosteric/allosteric antagonist |
120 |
3ODU [168] |
Class Aγ |
CXCR4 |
IT1t |
Antagonist |
121 |
3OE0 [168] |
Class Aγ |
CXCR4 |
CVX15 |
Antagonist |
122 |
3OE6 [168] |
Class Aγ |
CXCR4 |
IT1t |
Antagonist |
123 |
3OE8 [168] |
Class Aγ |
CXCR4 |
IT1t |
Antagonist |
124 |
3OE9 [168] |
Class Aγ |
CXCR4 |
IT1t |
Antagonist |
125 |
4MBS [170] |
Class Aγ |
CCR5 |
Maraviroc |
Antagonist |
126 |
5LWE [171] |
Class Aγ |
CCR9 |
Vercirnon |
Antagonist |
127 |
4EA3 [39] |
Class Aγ |
NOP |
Banyu Compound-24 (C-24) |
Antagonist |
128 |
5DHG [172] |
Class Aγ |
NOP |
Compound-35 (C-35) |
Antagonist |
129 |
5DHH [172] |
Class Aγ |
NOP |
SB-612111 |
Antagonist |
130 |
4DJH [173] |
Class Aγ |
κ-OR |
JDTic |
Antagonist |
131 |
4DKL [174] |
Class Aγ |
μ-OR |
Beta-FNA |
Antagonist |
132 |
5C1M [175] |
Class Aγ |
μ-OR |
BU72 |
Agonist |
133 |
4EJ4 [176] |
Class Aγ |
δ-OR |
Naltrindole |
Antagonist |
134 |
4N6H [70] |
Class Aγ |
δ-OR |
Naltrindole |
Antagonist |
135 |
4RWA [177] |
Class Aγ |
δ-OR |
Bifunctional Peptide H-Dmt(1)-Tic(2)-Phe(3)-Phe(4)-NH2 (DIPP-NH2) |
Antagonist |
136 |
4RWD [177] |
Class Aγ |
δ-OR |
Bifunctional Peptide H-Dmt(1)-Tic(2)-Phe(3)-Phe(4)-NH2 (DIPP-NH2) |
Antagonist |
137 |
4YAY [178] |
Class Aγ |
AT1R |
ZD7155 |
Antagonist |
138 |
4ZUD [179] |
Class Aγ |
AT1R |
Olmesartan |
Inverse Agonist |
139 |
5UNF [180] |
Class Aγ |
AT2R |
N-benzyl-N-(2-ethyl-4-oxo-3-{[2′-(2H-tetrazol- 5-yl)[1,1′-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin- 6-yl)thiophene-2-carboxamide |
|
140 |
5UNG [180] |
Class Aγ |
AT2R |
N-benzyl-N-(2-ethyl-4-oxo-3-{[2′-(2H-tetrazol- 5-yl)[1,1′-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin- 6-yl)thiophene-2-carboxamide |
|
141 |
5UNH [180] |
Class Aγ |
AT2R |
N-[(furan-2-yl)methyl]-N-(4-oxo-2-propyl- 3-{[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl}-3,4-dihydroquinazolin-6-yl)benzamide |
|
142 |
4XNW [182] |
Class Aδ |
P2Y1
|
MRS2500 |
Antagonist |
143 |
4XNV [182] |
Class Aδ |
P2Y1
|
BPTU |
Antagonist |
144 |
4NTJ [42] |
Class Aδ |
P2Y12
|
AZD1283 |
Antagonist |
145 |
4PXZ [183] |
Class Aδ |
P2Y12
|
2MeSADP |
Agonist |
146 |
4PY0 [183] |
Class Aδ |
P2Y12
|
2MeSADP |
Agonist |
147 |
3VW7 [71] |
Class Aδ |
PAR1 |
Vorapaxar |
Antagonist |
148 |
5EE7 [78] |
Class B |
GCGR |
MK-0893 |
Antagonist |
149 |
4K5Y [186] |
Class B |
CRF1R |
CP-376395 |
Antagonist |
150 |
4Z9G [187] |
Class B |
CRF1R |
CP-376395 |
Antagonist |
151 |
4OR2 [188] |
Class C |
mGlu1
|
FITM |
Negative Allosteric Modulator |
152 |
4OO9 [38] |
Class C |
mGlu5
|
Mavoglurant |
Negative Allosteric Modulator |
153 |
5CGC [189] |
Class C |
mGlu5
|
HTL14242 |
Antagonist |
154 |
5CGD [189] |
Class C |
mGlu5
|
HTL14242 |
Antagonist |
155 |
4JKV [40] |
Class F |
SMO |
LY2940680 |
Antagonist |
156 |
4N4W [190] |
Class F |
SMO |
SANT-1 |
Antagonist |
157 |
4O9R [131] |
Class F |
SMO |
Cyclopamine |
Antagonist |
158 |
4QIM [190] |
Class F |
SMO |
Anta XV |
Antagonist |
159 |
4QIN [190] |
Class F |
SMO |
SAG1.5 |
Agonist |
160 |
5L7D [93] |
Class F |
SMO |
Cholesterol |
|
161 |
5L7I [93] |
Class F |
SMO |
Vismodegib |
Antagonist |