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. 2018 Jun 19;9:443. doi: 10.3389/fneur.2018.00443

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Copyright © 2018 Ueda, Bando, Misumi, Ogawa, Ishida, Jung, Shimizu and Hida.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Motor map and dendrite expansion at 5 weeks of age. (A) A summary of the motor maps in Supplemental Figure 1 is shown as a heat map. Although map size at 5 weeks of age appears to be smaller than that at 10 weeks of age, the size of the hip area of the WMI group (n = 11) was unchanged compared with control animals (n = 9). (B) The number of blocks in the hip area was unaltered between groups. (C) The threshold for eliciting hip joint twitch was significantly higher in the WMI group. (D) Twenty-seven Golgi-positive neurons per animal were assessed by Sholl analysis in both ipsilateral and contralateral sensorimotor cortex of neonatal WMI model (n = 4) at 5 weeks of age. Sholl analysis revealed that the number of cross sections increased over 60 μm from cell bodies on the right side of the cortex, even at 5 weeks of age. *p < 0.05 and **p < 0.01 by Mann–Whitney U-tests. Data are presented as mean ± SEM.