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Alternative heme ruffling in IsdG and MhuD. (A) Represents the heme ruffling in IsdG and (B) Represents the heme ruffling in MhuD. Notice in (A), how the IsdG bends the heme so that the β- and δ-meso carbons are pushed away from the histidine, causing the α-meso carbon to move toward the ligand. In (B), MhuD bends the heme so that the β- and δ-meso carbons are closer to the histidine ligand.
