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. 2018 Jun 25;8:9584. doi: 10.1038/s41598-018-27836-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electron microscopy of RaegAdV-3085 infected Vero cells. (a) Numerous virions forming within the nucleus (N), with crystalline arrays evident within the granular matrix of an inclusion body (IB). Remnants of probable nuclear bodies are scattered throughout the nucleus (arrows). INSET: a negatively-stained virion; (b) developing virus particles within an inclusion body; (c) actin-like filaments (arrows) associated with developing virion; (d) fine, proteinaceous filaments extending between developing virions; (e) one of a series of serial sections through a crystalline array, showing the predominance of empty capsids around the periphery. Scale bars (d,e,f) = 80 nm.