Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 25;8:9645. doi: 10.1038/s41598-018-27927-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Morphology of generated iTH+ cells. (A) Change of fibroblast-like morphology of synovial adipose tissue-derived stem cells (sASC) to neuron-like morphology after 12 days of catecholaminergic differentiation (representative image of OA donor cells of one patient, magnification 200x). (B) Light microscopic appearance of OA iTHs after treatment with different concentrations and combinations of 10 ng/ml TNF and 1 or 10 µg/ml etanercept (ETA) (magnification 200x). (C) Light microscopic appearance of RA iTHs after treatment with same agents as in B (magnification 200x). (D) Number of fully differentiated dendritic-shaped cells after 12 days of catecholaminergic differentiation demonstrated as ratio of dendritic-shaped cells to total cell count (n = 8). Data are presented as box plots with the 10th, 25th, 50th (median), 75th, and 90th percentiles. Each black circle represents an individual patient sample. Significant p-values (p ≤ 0.05) against OA control are presented as “*”; against OA TNF group as “^#”; against RA control as “+”; against RA TNF group as “^§”; and differences between respective OA and RA groups as “^&”. Abbreviations: TNF10 = TNF 10 ng/ml; TNF1 = TNF 1 ng/ml; ETA1 = Etanercept 1 µg/ml; ETA10 = Etanercept 10 µg/ml.