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. 2018 Jun 25;8:9628. doi: 10.1038/s41598-018-27376-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of adipose tissue depot- and age-specific functional organisation of modules within each gene network. They were related individually by their first principal component, referred to as the module eigengene (ME). Each dendrogram illustrates the modules of co-expressed genes and their positive alignment within the ME at (A) 7 and (C) 28 days of age. The height (X-axis) indicates the magnitude of correlation expressed as Euclidean distances. Heat maps represent the correlation (and corresponding p-values) between co-expressed modules for each fat depot at (B) 7 and (D) 28 days of age. The colour scheme, from blue to red, indicates the magnitude of correlation, from low to high. Regional-specific modules identified as being highly correlated (i.e. over-expressed) for each adipose depot are shown in the columns.