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Simplified schematic illustration of the orthosteric and allosteric binding sites of nAChR subunits. A simplified schematic representation showing both the orthosteric and allosteric binding sites of nAChR subunits, including acetylcholine binding sites (orthosteric binding sites) located between the extracellular subunit interfaces, and the c-terminal binding sites and inter-subunit transmembrane sites (allosteric binding sites).
