Table 3.

Representative rare variants in nAChR subunits.

Subunit	Critical Substitution of nAChR Amino Acid Residue	Refs.
Alpha 2	T22I (rs2472553), D478N (rs141072985), D478E (rs563447740)	[222, 223]
Alpha 4	R336C, P451L, R487Q, S438D, S469A, Y576A, S589A, S516D, T536A, S247F, S252L, 776ins3, T529A	[199, 225-229]
Alpha 5	N143D, M145V, D398N (rs16969968)	[154, 233, 234, 239]
Alpha 6	S43P, N46K, D57N, R87C, D92E, R96H, E101K, A112V, S156R, N171K, A184D, D199Y, N203T, I226T, S233C.	[244-246]
Alpha 7	α7345-348A, D44A	[259-261]
Beta 2	V286L, V337G, V287L, V287M.	[199, 229-231]
Beta 3	V273S	[248, 255, 258]
Beta 4	R349C	[262]